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During systemic inflammation, the BBB is impacted via numerous processes, such as, activation of matrix metalloproteinases (MMPs), oxidative stress and free radical damage, and direct effects of circulating cytokines on tight junction proteins

A significant recent advancement, In-Cell FPOP of Membrane Proteins (IC-FPOMP), enables foot printing of integral membrane proteins, such as CFTR, within their native live-cell environment

Countries should treat cost limitations similarly to supply shortages: they should deploy policies that carefully prioritise specific populations rather than deny coverage [65]

George et al